Activated clotting time

Activated clotting time

Subclass of	blood clotting test

 

 From Wikidata

Waktuuji ɓuuɓɗi (ACT), anndiraaɗi kadi waktu ɓuuɓɗi, ko jarribo ɓuuɓgol.

Test ACT ina waawi huutoreede ngam yuurnitaade batte ɓuuɓri, ko wayi no ummoraade e heparin toowɗo hade, e nder, e ko juuti caggal golle ɗe njiɗ-ɗaa waɗde, ko wayi no ɓuuɓri ɓernde, kardiyoloji interventionnel, trombolyse, oksijen ekstrakorporeel membrane (ECMO), e diiyalis jokkondirɗo. Ina fotnoo leƴƴanɗe potɗe huutoreede ngam ƴiiƴam ɗam fof ɓuuɓta so tawii laawol ndernderiwol ngol ina huutoree e ɓeydagol ɓuuɓnooje faktor XII. Waktuuji ɓuuɓɗi ɗii tuugii ko e tolno gonɗo e mbaydi gonndi e mbaydi, ina ɗaɓɓi nafoore teskinnde ngam ƴeewndaade sabu ŋakkeende jokkondire hakkunde iwdi e formulaasiyoŋ kuutorteeɗo oo. Ina heewi yamireede e nder ngonkaaji ɗo ƴeewndo waktuuji tromboplastin (PTT) ina waawi ƴettude waktuuji ɓurɗi heewde ngam ƴeewndaade walla tawa alaa ko nafata e safaara. For example, systems that do not pre-warm the vial or sample may see increased time to clotting because clotting times increase with temperature.

Juutgol ACT ina waawi hollude ŋakkeende geɗe coagulation, trombositopeni, walla ŋakkeende golle ƴiiƴam. Pooɗondiral waktuuji ɓuuɓɗi ina waawi battinde e leɗɗe ko wayi no warfarin, aprotinin, e GpIIb/IIIa, e ŋakkeende fijirde ko wayi no hipotermi, hipervolemi, e hipovolemi.

Tariya Ko Hattersley adii waɗde ACT e hitaande 1966. Ko adii ɗuum, ngam yuurnitaade batte ɓuuɓri, ƴiiƴam ina waɗee e nder tuuba gilaas, ina reenee e 37 degere Celsius, ina huutoree e junngo haa ƴiiƴam ɗam natta ɓuuɓde. Nde yani e ƴeewtaade doseeji heparin e nder seppooji ɓernde sabu waktuuji cakkitiiɗi ɗii ina ɗaɓɓiree. So tawii ko dow tuuba gilaas oo ina huutoroo coagulation, waktu ɓuuɓɗo ina waawi ustaade e huutoraade activatoruuji goɗɗi ko wayi no celite e kaolin.

Laabi gollorɗi Ko ɓuri heewde e ƴiiƴam ina waɗee e nder ɓuuɓri walla e karte wondude e ɓuuɓri ƴiiƴam. Sammba oo ina jogaa e nguleeki toɗɗaandi, heewi wonde ko 37 degere Celsius. Toɓɓere joofnirde coagulation ina waawi anndeede e optik (yeru, ɓeydagol opacity yiytaa e sensor optik) walla sifaaji mekanik (yeru, ɓeydagol rigidity yiytaa e mbayliigu huunde e nder ɓuuɓri) ƴiiƴam ɓuuɓɗam. Previously, to monitor coagulation effects, blood was placed in a glass tube, kept at 37 degrees Celsius, and manually manipulated until the blood was no longer fluid. It fell out of favor to monitor heparin dosing during cardiac surgery because of the dedicated time required. While the glass tube surface activated coagulation, the clotting time could be decreased with the use of other activators like celite and kaolin.

Sappinolji

Njeñtudi ndii ina waawi seertude fawaade e kaɓirɗe e laabi kuutorteeɗi ɗii. Yeru, sisteemuuji ɗi ɓuuɓnataa ko adii ɓuuɓri walla sample ina mbaawi yiyde ɓeydagol waktuuji ɓuuɓgol sabu waktuuji ɓuuɓgol ina ɓeydoo e nguleeki. Ko ɓuri heewde e limtooji ko hakkunde 70 e 120 leƴƴannde. Wonande ñawɓe wonduɓe e antikoagulant, waktu oo ina ɓeydoo.