Granulovacuolar degeneration
Degeneraasiyoŋ granulovakuolar ko feeñde e nder neeruuji ɓuuɓɗi ɗi ngalaa no mbayi, ɗi keewi ndiyam (vacuoles) ina njogii ɓuuɓri poroteyiin denndaandi. Granulovacuoles ɓuri heewde feeñde ko e neronuuji piramidaaji hippokampus. Ɗe ina tawee e mawɓe ɓe ngalaa dementia, kono ina ɓeydoo heewde e ñawu Alzheimer e tauopathies goɗɗe. E nder ñawu Alzheimer, granulovacuoles ina ɓeydoo heewde e nokkuuji ngaandi ceertuɗi, tee keeweendi mum en ina jokkondiri e tolno tauopati, patoloji plaque Abeta, e anjiyopati amiloid cerebral. Annduɓe immunohistochimique kollitii wonde ƴiiƴam nder ɓalndu ina waɗi poroteyiinuuji keewɗi, ina heen poroteyiin tubulin tau, TDP-43 e goɗɗi. Hay so tawii granulovakuoles e nafoore mum en e golle ina pamɗi haa jooni, ɗe nanndiraama e vakuoles otofaaji
Degeneraasiyoŋ granulovakuolar (kuɗol ina hollita ɓuuɓri wootiri) e nder sitoplasma neeruuji piramidaaji e nder mbaydi hippokampal neɗɗo mo ñawu Alzheimer. Hematoksilin e mbaydi eosin. Barme njuuteendi = 20 mikroo (0,02mm).
Tuugnorgal[1][2] Although granulovacuoles and their functional significance are still poorly understood, they have been compared to autophagic vacuoles [3] [4] [5]
[taƴto | taƴto ɗaɗi wiki]- ↑ Adams, J. Hume; Corsellis, J.A.N.; Duchen, L.W. (1984). Greenfield's Neuropathology (4th ed.). New York: John Wiley and Sons. pp. 24, 966–967. ISBN 0-471-82307-4.
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs namedThal 2011 - ↑ Köhler C (2016). "Granulovacuolar degeneration: a neurodegenerative change that accompanies tau pathology". Acta Neuropathologica. 132 (3): 339–359. doi:10.1007/s00401-016-1562-0. PMID 27062260.
- ↑ Köhler C (2016). "Granulovacuolar degeneration: a neurodegenerative change that accompanies tau pathology". Acta Neuropathologica. 132 (3): 339–359. doi:10.1007/s00401-016-1562-0. PMID 27062260.
- ↑ Adams, J. Hume; Corsellis, J.A.N.; Duchen, L.W. (1984). Greenfield's Neuropathology (4th ed.). New York: John Wiley and Sons. pp. 24, 966–967. ISBN 0-471-82307-4.