Nemosis
Nemosis ko feere ɓuuɓnde e maayde e nder fibroblasteeji neɗɗo..[1][2][3][4] Fuɗɗoode yiytaa ko nekrosis porogaraam,[2] innde nemosis, ko iwdi Debbo Nemesis e nder daartol Gerek en. Ndee innde ƴettaa ko ngam ustude fibroblasteeji tuugiiɗi e fuɗɗoode mum e jokkondiral hakkunde ɓiɗɓe leɗɗe e ɓiɗɓe leɗɗe, ko wayi no ɓurondiral jokkondiral hakkunde ƴiiƴam (ECM). Jokkondiral hakkunde fibroblasteeji diploid no woorunoo ina addana ƴiiƴam ɓuuɓde, addana ɗum maayde ƴiiƴam porogaraam, PCD. Ooɗoo sifaa PCD ina jogii sifaaji nekrosis wonaa apoptosis.
Nemosis fibroblasteeji, walla ƴiye mesenkeem e nder kuuɓal, ina addana ɓuuɓri keewndi, ko wayi no prostaglandines,[2] kam e geɗe mawnugol ko wayi no geɗe mawnugol hepatosiit.[1] Ko noon hollirtee ina wallita e geɗe bayɗe no ɓuuɓri ɓuuɓndi e ɓuuɓndi, e kanseer. Geɗe ɗe fibroblasteeji nemotik njiylotoo ɗii kadi ina mbonna ECM. Ko wayi no geɗe keewɗe ina mbaɗi metaloproteinaaseeji matriks,[3] e ƴellitgol plasminogen.[2]
Tuugnorgal
[taƴto | taƴto ɗaɗi wiki]- ↑ Esko Kankuri; Dana Cholujova; Monika Comajova; Antti Vaheri; Jozef Bizik (2005). "Induction of hepatocyte growth factor/scatter factor by fibroblast clustering directly promotes tumor cell invasiveness". Cancer Research. 65 (21): 9914–9922. doi:10.1158/0008-5472.CAN-05-1559. PMID 16267016.
- ↑ Jozef Bizik; Esko Kankuri; Ari Ristimäki; Alain Taieb; Heikki Vapaatalo; Werner Lubitz; Antti Vaheri (2004). "Cell-cell contacts trigger programmed necrosis and induce cyclooxygenase-2 expression". Cell Death and Differentiation. 11 (2): 183–195. doi:10.1038/sj.cdd.4401317. PMID 14555963.
- ↑ Vappu Sirén; Pertteli Salmenperä; Esko Kankuri; Jozef Bizik; Timo Sorsa; Taina Tervahartiala; Antti Vaheri (2006). "Cell-cell contact activation of fibroblasts increases the expression of matrix metalloproteinases". Annals of Medicine. 38 (3): 212–220. doi:10.1080/07853890500494999. PMID 16720435. S2CID 25178764.
- ↑ Esko Kankuri; Olga Babusikova; Kristina Hlubinova; Pertteli Salmenperä; Carla Boccaccio; Werner Lubitz; Ari Harjula; Jozef Bizik (2007). "Fibroblast nemosis arrests growth and induces differentiation of human leukemia cells". International Journal of Cancer. 122 (6): 1243–52. doi:10.1002/ijc.23179. PMID 18027855.